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. 2019 Apr 26;10:385. doi: 10.3389/fneur.2019.00385

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Copyright © 2019 Martino, Hartmann, Pelosin, Lagravinese, Delorme, Worbe and Avanzino.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Movement lateralization: timing performance of the right hand (RH) on the single-hand task (UNI) and on the bimanual task (BI). Data of both patients with Tourette syndrome (TS) and healthy control subjects (HC) are shown. The results of the synchronization (SYNC) and continuation (CONT) tasks with a supra-second (0.5 Hz, 2,000 ms ISI) and sub-second (2 Hz, 500 ms ISI) time interval are shown. On the x-axis, we show the type of task. On the y-axis, we show the duration of the temporal error in ms (A,B) and the IRA expressed as a ratio between the time interval reproduced by the subject and the time interval set by the metronome (C,D). Asterisks indicate when statistical analysis showed a significant difference (*p < 0.05). Mean data + standard error mean (SEM) are shown.