Table 4.

Genome-wide significant loci using PC-GWAS approach.

Peak SNP	AF	Association count	Chr	BP (GRCh37)	Gene	Pooled analysis P-value
rs7296503	0.723	2	12	41700764	PDZRN4+	2.10E-09
rs112505971	0.948	21	10	27357470	ANKRD26	1.81E-08
rs4837892	0.652	1	9	124588304	TTLL11	2.99E-08
rs9917425	0.819	4	20	16736045	OTOR+	6.77E-10
rs3840870	0.556	1	17	48262183	COL1A1	1.19E-08
rs334	0.923	22	11	5244665	HBB∗+	1.15E-12
rs76792961	0.897	209	16	293593	ITFG3∗+	6.70E-26
rs2853961	0.603	1	6	31231989	HLA-C∗+	4.25E-08

^∗Known association; AF, allele frequency. ⁺Locus remain significant after applying Bonferroni corrected threshold of 3.33 × 10⁻⁹.