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. 2019 Apr 26;12:102. doi: 10.3389/fnmol.2019.00102

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Copyright © 2019 A, Zou, He, Chen, Sun, Fan and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protein–protein interaction analysis of the retina in metformin-treated and PBS-treated rd1 mice at P14. The gene-act-network was constructed based on the interactions among genes identified in the STRING database. Each node (blue circle) represents a gene. Lines represent interactive relationships between two signaling pathways. We represent the significance of differences in genes in terms of the size of the circle, and the clustering coefficient is represented by the shade of the circle in blue. A darker color indicates more associated genes.