Table S2.
Glucagon and GLP-1 related parameters during OGTT
| Parameters | Young groupa | Old group (n=10)a | Correlation with MBW-valueb | Correlation with MFFM-valueb |
|---|---|---|---|---|
| Baseline glucagon (pmol/L) | – | 8.8±6.3 (71.8) | 0.011 (0.976) | −0.030 (0.935) |
| Cmin of glucagon (pmol/L) | – | 2.8±2.7 (97.2) | 0.137 (0.707) | 0.089 (0.807) |
| AUC of glucagon (pmol·h/L) | – | 547.3±450.6 (82.3) | −0.030 (0.934) | −0.006 (0.987) |
| Baseline active GLP-1 (pmol/L) | – | 7.8±7.2 (92.6) | −0.455 (0.187) | −0.503 (0.138) |
| Cmax of active GLP-1 (pmol/L) | – | 11.9±9.1 (76.5) | −0.079 (0.829) | −0.152 (0.676) |
| AUC of active GLP-1 (pmol·h/L) | – | 1118.9±783.6 (70.0) | −0.152 (0.676) | −0.212 (0.556) |
| Baseline total GIP (pmol/L) | – | 23.6±18.5 (78.1) | 0.304 (0.393) | 0.292 (0.413) |
| Cmax of total GIP (pmol/L) | – | 415.2±173.6 (41.8) | 0.361 (0.305) | 0.420 (0.226) |
| AUC of total GIP (pmol·h/L) | – | 38,351.9±16,783.0 (43.8) | 0.248 (0.489) | 0.224 (0.533) |
Notes: aPlasma levels of glucagon, active GLP-1, and total GIP were measured in 10 subjects in the elderly group. bValues are presented as correlation coefficient (P-value) and significant correlation was considered at P<0.05.
Abbreviations: GIP, glucose-dependent insulinotropic polypeptide; GLP-1; glucagon-like peptide-1, OGTT, oral glucose tolerance.