Table 1.
Univariate and multivariate logistic regression analysis for risk factors of HCC recurrence
| Parameter | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| OR | 95% CI | p | OR | 95% CI | p | |
| Gender | 0.841 | 0.157–4.506 | 0.840 | - | - | - |
| Age | 1.249 | 0.409–3.812 | 0.696 | - | - | - |
| Number | 2.256 | 0.674–7.556 | 0.187 | - | - | - |
| Size | 4.765 | 1.635–13.891 | 0.004** | 13.630 | 1.004–185.083 | 0.050 |
| Gross vascular invasion | 11.282 | 1.416–89.878 | 0.022* | 0.014 | 0–2.654 | 0.111 |
| Microvascular invasion | 3.033 | 1.121–8.212 | 0.029* | 2.056 | 0.195–21.629 | 0.548 |
| Cirrhosis | 1.620 | 0.354–7.411 | 0.534 | - | - | - |
| Differentiation | 1.728 | 0.626–4.768 | 0.291 | - | - | - |
| AJCC stage | 17.333 | 2.19–137.209 | 0.007** | 1.904 | 0.014–264.541 | 0.798 |
| BCLC stage | 13.327 | 2.861–62.088 | 0.001** | 37.874 | 0.811–1768.191 | 0.064 |
| HBV copies | 0.835 | 0.306–2.281 | 0.725 | - | - | - |
| PGK1 | 4.274 | 1.44–12.683 | 0.009* | 145.028 | 3.441–6112.214 | 0.009** |
| AFP | 22.105 | 4.693–104.127 | <0.001*** | 24.097 | 2.401–241.839 | 0.007** |
Notes: Multivariate analysis was done using the Cox multivariate proportional hazard regression model with stepwise manner (forward, likelihood ratio). *p<0.05; **p<0.01; ***p<0.001.
Abbreviations: AJCC, American Joint Committee on Cancer; BCLC, Barcelona Clinic Liver Cancer; HBV, hepatitis B virus ; AFP, α-fetoprotein; -, not available.