Table 2.

Results of subgroup analysis

Subgroups	Studies	Sensitivity [95% CI]	Specificity [95% CI]	PLR [95% CI]	NLR [95% CI]	DOR [95% CI]	AUC [95% CI]
Specimen
Tissue	20	0.75[0.69–0.80]	0.75[0.69–0.80]	3.0[2.6–3.5]	0.33[0.28–0.40]	9[7–11]	0.81[0.78–0.85]
Other	12	0.84[0.72–0.91]	0.70[0.56–0.82]	2.8[1.9–4.2]	0.23[0.14–0.38]	12[7–23]	0.84[0.81–0.87]
Case size
≥100	17	0.82[0.72–0.89]	0.70[0.61–0.78]	2.8[2.2–3.5]	0.25[0.17–0.37]	11[8–16]	0.82[0.79–0.85]
<100	15	0.74[0.69–0.79]	0.77[0.69–0.83]	3.2[2.4–4.2]	0.34[0.28–0.40]	10[7–13]	0.81[0.77–0.84]
Cancer type
GC	16	0.80[0.69–0.87]	0.71[0.61–0.79]	2.7[2.1–3.5]	0.29[0.20–0.41]	9[6–14]	0.81[0.78–0.85]
Other	16	0.78[0.71–0.83]	0.76[0.70–0.82]	3.3[2.6–4.0]	0.29[0.24–0.37]	11[8–15]	0.84[0.80–0.87]
Overall	32	0.79[0.73–0.84]	0.73[0.67–0.79]	2.9[2.5–3.5]	0.29[0.24–0.36]	10[8–13]	0.83[0.79–0.86]

Abbreviations: GC, gastric cancer; PLR, positive likelihood ratio; NLR, negative likelihood ratio; DOR, diagnostic odd ratio; AUC, area under the curve.