. 2019 Mar 27;12:1041–1051. doi: 10.2147/JPR.S187249

Table 3.

Multivariate generalized linear regression for NRS pain score at rest on POD 0–3 and adjuvant analgesics use after major laparoscopic abdominal surgery in 2010–2016

Variables	Exp. Coefficient (95% CI)	P-value
NRS pain score on POD 0
Preperative CRP, mg dl⁻¹ (model 1)	-0.002 (-0.003, 0.000)	0.085
Postoperative CRP, mg dl⁻¹ (model 1)	0.001 (0.000, 0.003)	0.136
Increase of CRP, mg dl⁻¹ (model 2)	0.001 (0.000, 0.003)	0.049
NRS pain score on POD 1
Preperative CRP, mg dl⁻¹ (model 1)	-0.002 (-0.003, 0.000)	0.059
Postoperative CRP, mg dl⁻¹ (model 1)	0.003 (0.001, 0.004)	<0.001
Increase of CRP, mg dl⁻¹ (model 2)	0.002 (0.001, 0.003)	<0.001
NRS pain score on POD 2
Preperative CRP, mg dl⁻¹ (model 1)	-0.001 (-0.003, 0.000)	0.145
Postoperative CRP, mg dl⁻¹ (model 1)	0.006 (0.004, 0.007)	<0.001
Increase of CRP, mg dl⁻¹ (model 2)	0.004 (0.002, 0.005)	<0.001
NRS pain score on POD 3
Preperative CRP, mg dl⁻¹ (model 1)	0.000 (-0.002, 0.002)	0.800
Postoperative CRP, mg dl⁻¹ (model 1)	0.007 (0.005, 0.009)	<0.001
Increase of CRP, mg dl⁻¹ (model 2)	0.004 (0.002, 0.005)	<0.001
Acetaminophen (mg) use in POD 0-3
Preperative CRP, mg dl⁻¹ (model 1)	-0.010 (-0.018, 0.003)	0.129
Postoperative CRP, mg dl⁻¹ (model 1)	0.004 (-0.001, 0.008)	0.058
Increase of CRP, mg dl⁻¹ (model 2)	0.006 (-0.003, 0.015)	0.157
Ketorolac use (mg) in POD 0-3
Preperative CRP, mg dl⁻¹ (model 1)	0.005 (-0.013, 0.024)	0.555
Postoperative CRP, mg dl⁻¹ (model 1)	-0.021 (-0.039, 0.007)	0.251
Increase of CRP, mg dl⁻¹ (model 2)	-0.016 (-0.030, 0.020)	0.532

Note: All covariates were included for adjustment in each multivariate generalized linear models.

Abbreviations: NRS, numeric rating scale; POD, postoperative day; Exp, exponentiated regression; CI, confidence interval; CRP, C-reactive protein.