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. 2019 Mar 29;11:2531–2543. doi: 10.2147/CMAR.S199818

Figure 2.

Figure 2

miR-944 inhibits the proliferation and clone formation and induces apoptosis in HCC cells. (A) The transfection efficiency of miR-944 mimics and a miR-944 inhibitor was assessed by RT-qPCR. miR-944 was significantly upregulated in Hep3B cells, while it was efficiently knocked down in Huh7 cells. *P<0.05 vs miR-NC. #P<0.05 vs NC inhibitor. (B) CCK-8 assays indicated that overexpression of miR-944 attenuated the proliferation of Hep3B cells, while miR-944 silencing promoted Huh7 cell proliferation. *P<0.05 vs miR-NC. #P<0.05 vs NC inhibitor. (C) miR-944 upregulation clearly decreased the clone formation of Hep3B cells, while miR-944 knockdown had the opposite effect on Huh7 cells. *P<0.05 vs miR-NC. #P<0.05 vs NC inhibitor. (D) The percentage of apoptotic Hep3B cells increased after transfection with miR-944 mimics, whereas the apoptosis rate was suppressed in miR-944 inhibitor-transfected Huh7 cells. *P<0.05 vs miR-NC. #P<0.05 vs NC inhibitor.