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. 2019 Mar 29;11:2531–2543. doi: 10.2147/CMAR.S199818

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© 2019 Lv et al.

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Modulation of IGF-1R partially rescues the miR-944-mediated metastasis and EMT of HCC cells. (A and B) miR-944 mimics-transfected Hep3B cells were co-transfected with pc-IGF-1R, while si-IGF-1R and si-NC were introduced into Huh7 cells that were transfected with a miR-944 inhibitor. Cell migration and invasion assays were conducted to determine the migration and invasion capacities of the transfected HCC cells. *P<0.05 vs miR-NC. **P<0.05 vs miR-944 mimics+pcDNA3.1. ^#P<0.05 vs NC inhibitor. ^##P<0.05 vs miR-944 inhibitor+si-NC.(C) Western blotting analysis was utilized to measure the protein levels of E-cadherin, N-cadherin, and vimentin in Hep3B and Huh7 cells treated as described. ×200 magnification.