Table 2.
Posaconazole serum AUC/MIC target for aspergillosis and mucormycosis
| Fungal culture | MIC of posaconazole (mg/L) |
Target of AUC/MIC ratio |
AUC0-12/MIC ratio | AUC0-24/MIC ratio | ||||
|---|---|---|---|---|---|---|---|---|
| 300 mg q 12 hrs (day 1) | 400 mg q 24 hrs (day 7) |
400 mg q 24 hrs (day 14) |
300 mg q 24 hrs (day 35) |
|||||
| Aspergillosis | A. fumigatus | 0.01 | 300–500 | 815.15 | 1,630.30 | 7,618.43 | 7,746.44 | 4,923.02 |
| A. flavus | 0.12 | 300–500 | 67.93 | 135.86 | 634.87 | 645.54 | 410.25 | |
| Mucormycosis | R. microsporus | 0.25 | >100 | 32.61 | 65.21 | 304.74 | 309.86 | 196.92 |
| L. corymbifera | 0.25 | >100 | 32.61 | 65.21 | 304.74 | 309.86 | 196.92 | |
Abbreviations: MIC, minimum fungicidal inhibitory concentration; AUC/MIC ratio, area under concentration-time curve over minimum fungicidal inhibitory concentration (MIC); AUC0-12, area under concentration-time curve from 0 to 12 hrs; AUC0-24, area under concentration-time curve from 0 to 24 hrs.