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. 2019 Apr 18;12:1287–1296. doi: 10.2147/JPR.S197168

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© 2019 Cao et al.

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TRPM8 blocker reduces cold pain, aggravates thermal pain but has no effect on mechanical pain in chronic constriction injury (CCI) rats. (A) Cold pain sensitivity assessed by cold plate tests, which significantly decreased in AMTB group compared with CCI group on the 3rd, 7th, 10th and 14th day after CCI surgery. (B) The thermal withdrawal latencies assessed by a beam-thermal system were decreased in AMTB rats compared with CCI rats on the 3rd, 7th, 10th and 14th day after CCI surgery. (C) Mechanical withdrawal thresholds (MWTs) were assessed with the electronic von Frey plantar aesthesiometer on ipsilateral hind paws of CCI, CCI+TRPM8 blockade and sham-operated rats, which showed no obvious change between CCI and AMTB group. Data are expressed as mean±SD, n=12 for the three experiments. Statistical analyses consisted of repeated measures two-way ANOVA tests. *P<0.05 vs Sham group, ^#P<0.05 vs CCI group.