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. 2019 Apr 10;11:2977–2985. doi: 10.2147/CMAR.S193647

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© 2019 Zhang et al.

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Effect of SHP-1 siRNA transfection on chrysin inhibition of sphere formation, upregulation of SHP-1 expression and decreasing expression of p-STAT3 and Twist1 in SMMC-7721 cells. (A) SHP-1 siRNA transfection abrogated chrysin’s inhibition of sphere formation in SMMC-7721 cells. Representative phase contrast microscopy images are shown (×10). (B) statistical analysis of sphere formation rate (mean ± SD; n=9). *p<0.05 vs control; ^#p<0.05 vs SMMC-7721 cells transfected with si-SHP-1. (C, E, and G) Representative blot from three independent experiments. (D, F, and H) relative density or phosphorylation of target band (mean ± SD; n=3); *p<0.05 vs control; ^#p<0.05 vs SMMC-7721 cells transfected with si-SHP-1.