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. 2019 Apr 8;11:2769–2781. doi: 10.2147/CMAR.S194073

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© 2019 Zhang et al.

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Exogenous miR-877 expression inhibits proliferation and colony formation and promotes apoptosis of CRC cells. (A) SW480 and HCT116 cells were transfected with miR-877 mimics or miR-NC. RT-qPCR was performed at 48 h post-transfection to measure miR-877 expression. *P<0.05 versus miR-NC. (B) CCK-8 assay was employed to determine the proliferation of SW480 and HCT116 cells transfected with miR-877 mimics or miR-NC. *P<0.05 versus miR-NC. (C) Effect of miR-877 overexpression on colony formation ability of SW480 and HCT116 cells was examined using colony formation assay. *P<0.05 versus miR-NC. (D) Apoptosis rate in SW480 and HCT116 cells after transfection with miR-877 mimics or miR-NC was detected using annexin V-fluorescein isothiocyanate (FITC) apoptosis detection kit. *P<0.05 versus miR-NC.