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. 2019 Apr 8;11:2769–2781. doi: 10.2147/CMAR.S194073

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© 2019 Zhang et al.

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miR-877 inhibits CRC tumor growth in vivo. (A) Tumor xenografts derived from SW480 cells transfected with miR-877 mimics or miR-NC. (B) Tumor length and width were measured every 4 days, and tumor volumes were calculated using the following formula: tumor volume (mm³) = width² (mm²) × length (mm)/2. *P<0.05 versus miR-NC. (C) After 30 days, all mice were sacrificed, and xenografts were excised and weighed. *P<0.05 versus miR-NC. (D) RT-qPCR was utilized to determine miR-877 expression in tumor xenografts derived from SW480 cells transfected with miR-877 mimics or miR-NC. *P<0.05 versus miR-NC. (E) Expression levels of MTDH, PTEN, p-Akt, and Akt in tumor xenografts were detected using western blotting analysis.