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. 2019 Mar 27;11:2405–2414. doi: 10.2147/CMAR.S196273

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© 2019 Peng et al.

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Schematic illustration of roles of clusterin in the cancer metastasis with a function of EMT. TGF-β upregulated CLU expression which was repressed by overexpression of c-Fos proto-oncogene, resulting EMT and cancer invasion.