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. 2019 Mar 27;11:2405–2414. doi: 10.2147/CMAR.S196273

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© 2019 Peng et al.

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Comprehensive overview of the role of Clusterin on apoptosis-related events in cancer cells. (A) (black): Ionization Radiation, and DNA damage stimulated ATM-IGF-1–MAPK–CLU signaling pathway in the absence or presence of p53 (reference 33); (B) (green): Clusterin promotes TNF-α-induced activation of NF-κB and increases the expression of Bcl-2; (C) (red): Clusterin stabilized IκB, decreased transcription of the NF-κB target gene and up-modulated p53 protein; and (D) (yellow): Clusterin prevents cell death through stabilizing the association between Ku70 and Bax, thereby inhibiting the release of Cytochrome c from the mitochondria.