Figure 3.

Development of the lesion during 12 weeks. T2-weighted MR images of two selected coronal positions through the brain of a representative mouse are shown at 48 h and for time points every two weeks following dMCAO. The slice positions were selected as described in Fig. 2. The hyperintensity at 48 h quickly fades away, and only in the lower row at the level of the hippocampus a small hyperintense spot at the cortical surface remains at later times. In this plane, the movement of the hippocampus towards the brain surface with time is clearly noted. In the upper row of images at the level of the MCA coagulation (cf Fig. 2), the increasing thinning of the cortex is visible together with the pronounced bending of the corpus callosum towards the brain surface on the site of coagulation.