Table 3.
Autoimmune Disorders in Patients With CAH Due to 21OHD Divided Into Phenotypes and Compared With Age- and Sex-Matched Controls (100 Controls Per Case)
| Variable | SW | SV | NC | ||||||
|---|---|---|---|---|---|---|---|---|---|
| All (n = 288) | Female Patients (n = 157) | Male Patients (n = 131) | All (n = 188) | Female Patients (n = 101) | Male Patients (n = 87) | All (n = 90) | Female Patients (n = 67) | Male Patients (n = 23) | |
| Mean age ± SD, y | 24.5 ± 16.1 | 25.3 ± 15.6 | 23.6 ± 16.7 | 32.5 ± 19.3 | 32.2 ± 17.5 | 32.8 ± 21.3 | 29.3 ± 15.9 | 30.2 ± 15.7 | 26.7 ± 16.4 |
| Any autoimmune disorder | 12 (4.2) | 9 (5.7) | 3 (2.3) | 17 (9.0)a | 8 (7.9) | 9 (10.3)a | 10 (11.1)a | 8 (11.9)a | 2 (8.7) |
| Autoimmune endocrine disorder | 4 (1.4) | 2 (1.3) | 2 (1.5) | 4 (2.1) | 2 (2.0) | 2 (2.3) | 6 (6.7)a,b | 5 (7.5)a,b | 1 (4.4) |
| Type 1 diabetes | 4 (2.1) | 2 (2.0) | 2 (2.3) | 2 (2.2) | 2 (3.0)a | ||||
| Autoimmune thyroid disease | 4 (1.4)a,b | 2 (1.3) | 2 (1.5)a,b | 4 (4.4)a,b | 3 (4.5)a,b | 1 (4.4)a | |||
| Graves disease | 3 (1.0)a,b | 1 (0.6) | 2 (1.5)a,b | 4 (4.4)a,b | 3 (4.5)a,b | 1 (4.4)a | |||
| Autoimmune thyroiditis | 1 (0.4) | 1 (0.6) | |||||||
| Autoimmune GI disorder | 3 (1.0) | 3 (1.9) | 7 (3.7)a | 2 (2.0) | 5 (5.6)a,b | ||||
| IBD | 3 (1.0) | 3 (1.9)c | 5 (2.7)a | 1 (1.0) | 4 (4.6)a,b | ||||
| Cholangitis | 1 (0.5)a | 1 (1.0)a | |||||||
| Celiac disease | 1 (0.5) | 1 (1.2) | |||||||
| Autoimmune skin disorder | 3 (1.0) | 3 (1.9) | 3 (1.6) | 3 (3.0) | 1 (1.1) | 1 (1.5) | |||
| Psoriasis | 3 (1.0) | 3 (1.9) | 3 (1.6) | 3 (3.0)c | 1 (1.1) | 1 (1.5) | |||
| Rheumatic disease | 2 (0.7) | 1 (1.2) | 1 (0.8) | 6 (3.2)a | 4 (4.0)c | 2 (2.3) | 3 (3.3)c | 2 (3.0) | 1 (4.4) |
| RA | 2 (1.1) | 1 (1.0) | 1 (1.2) | 1 (1.1) | 1 (1.5) | ||||
| Systemic CTD | 1 (0.4) | 1 (0.6) | 4 (2.1)a | 3 (3.0)a | 1 (1.2) | 2 (2.2) | 1 (1.5) | 1 (4.4)c | |
| Ankylosing spondylitis | 1 (0.4) | 1 (0.8)c | 1 (0.5) | 1 (1.0)c | |||||
Unless otherwise noted, values are n (%). The numbers are not displayed if no patient had the condition but analysis showed P > 0.10. Autoimmune thyroiditis is often called Hashimoto thyroiditis.
Abbreviations: CTD, connective tissue disorders; GI, gastrointestinal; RA, rheumatoid arthritis.
a
P < 0.05.
b
P < 0.01
c
P = 0.05–0.09.