Table 5.
Any Autoimmune Disorders in Individuals With CAH Due to 21OHD Deficiency in Different Age Groups Compared With Age- and Sex-Matched Controls (100 Controls per Case)
| Variable | Age 0–18 y | Age 19–39 y | Age ≥40 y | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Patients With CAH | Controls | P Value | Patients With CAH | Controls | P Value | Patients With CAH | Controls | P Value | |
| All patients | |||||||||
| Patients, n | 215 | 21 948 | 295 | 29 629 | 204 | 19 823 | |||
| Patients with any autoimmune disorder, n (%) | 4 (1.9) | 383 (1.7) | 0.79 | 18 (6.1) | 1497 (5.1) | 0.42 | 21(6.8%) | 1279(4.1%) | <0.01 |
| RR (95% CI) | 1.07 (0.40–2.83) | 1.21 (0.77–1.89) | 1.74 (1.26–2.42) | ||||||
| Female patients | |||||||||
| Patients, n | 108 | 11 142 | 180 | 18 011 | 116 | 11 247 | |||
| Patients with any autoimmune disorder, n (%) | 2 (1.9) | 206 (1.8) | 1 | 9 (5.0) | 1 016 (5.6) | 0.89 | 21(18.1%) | 1 107(9.8%) | <0.01 |
| RR (95% CI) | 1.00 (0.25–3.98) | 0.89 (0.47–1.68) | 1.84 (1.24–2.72) | ||||||
| Male patients | |||||||||
| Patients, n | 107 | 10 806 | 115 | 11 618 | 88 | 8 576 | |||
| Patients with any autoimmune disorder, n (%) | 2 (1.9) | 177 (1.6) | 0.70 | 9 (7.8) | 481 (4.1) | <0.05 | 10(11.4%) | 621(7.2%) | 0.15 |
| RR (95% CI) | 1.14 (0.29–4.54) | 1.89 (1.00–3.56) | 1.57 (0.87–2.83) | ||||||