Table 2.

Association Between Dose of Spironolactone and Hyperkalemia

Dose of Spironolactone	Number of Potassium Measurements >5.0 mmol/L/Total Number of Potassium Measurements (%)	Relative Risk (95% CI)	P Value
<100 mg/d	2/17 (11.8)	1.0
100–200 mg/d	2/74 (2.7)	0.23 (0.03–1.52)	0.13
>200 mg/d	3/98 (3.1)	0.26 (0.05–1.44)	0.12

Baseline potassium measurements were excluded. A spironolactone dose of 100 mg/d was the most common starting dose. A dose of spironolactone <100 mg/dL was designated as the reference. There was no increased risk of hyperkalemia with higher spironolactone dose categories.