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Intracellular localization of designed K-Ras4B mutants in cultured NIH3T3 cells using fluorescence microscopy. Transfected K-Ras4B alleles were visualized with anti-K-Ras immunofluorescence and the actin cytoskeleton highlighted with fluorescently-tagged phalloidin. Images are shown for Ev, K-Ras4B.G12V, and designed K-Ras mutants G12V/D92N, G12V/D126N, G12V/K104M. Ev, indicates untransformed cells, and K-Ras4B.G12V was included as positive control.
