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. 2019 Mar 1;294(17):6785–6795. doi: 10.1074/jbc.RA118.006255

Figure 1.

Figure 1.

The IL-32 gene is silenced by DNA methylation in HEK293 cells. A, RNA-Seq results showed that 5-aza-dC treatment activates IL-32 expression in HEK293 cells. The asterisk indicates that the FPKM values were added a pseudocount of 0.5 to avoid being divided by zero. B, IL-32 FPKM values in 5-aza-dC- and DMSO-treated samples. C, schematic representation of the IL-32 promoter and CGI. D, locus-specific bisulfite sequencing results revealed that the promoter and CGI of IL-32 are highly methylated in HEK293 cells.