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NMK-T-057 down-regulates active Notch (NICD) expression in vivo in 4T1-BALB/c tumors. A, photographs representing immunohistochemistry of NICD in control and NMK-T-057 (10, 25, and 50 mg/kg-BW)-treated tumors. The photographs represents the best of the replicates (n = 3). Scale bars, 10 μm. B, Western blot of NICD in tumors of control and treated groups. C, schematic representation of the mechanism of action of NMK-T-057 in breast cancer.
