FIG 3.

Examples of kinetics of serum biomarkers in patients with invasive candidiasis (IC) (A), invasive aspergillosis (IA) (B), and mucormycosis (MM) (C). Day 0 indicates the date of a positive fungal blood culture (BC) for IC or the first available serum sample for IA and the date of mycological evidence for MM. (A, B) Black circles and black solid line, MS-DS; black triangles and dashed line, Man or GM detection; black squares and gray line, BDG detection. Biomarker levels are indicated on the y axis with reference to BDG values (pg/ml), MS-DS index, and GM (index × 1,000). (C) Empty and full circles, negative and positive Mucorales qPCR results, respectively, for MM patients. Horizontal dotted lines indicate the cutoff values for BDG (80 pg/ml), Man (62.5 pg/ml), GM (index value, 0.5 · 1,000), and MS-DS (index value, 325). d, day.