TABLE 1.
Origin of sera from patients with IC, delay between serum sampling and time of first positive blood culture, and Candida species isolateda
| Patient no. (site) | Species isolated | Delay vs BC (days) | Man concn (pg/ml) | BDG concn (pg/ml) | MS-DS index |
|---|---|---|---|---|---|
| I1 (G) | Candida albicans | 2 | >500 | 688 | 2,000 |
| C. albicans | 5 | >500 | 1,528 | 550 | |
| C. albicans | 7 | >500 | 861 | 625 | |
| I2 (G) | C. albicans | 2 | 81 | 943 | 79 |
| C. albicans | 5 | 192 | 405 | 133 | |
| C. albicans | 7 | 79 | 286 | 200 | |
| I3 (G) | C. albicans | 2 | 69 | 155 | 400 |
| C. albicans | 7 | 30 | 108 | 526 | |
| C. albicans | 13 | 12 | 50 | 300 | |
| I4 (G) | C. albicans | 0 | >500 | 5,000 | 1,000 |
| C. albicans | 5 | >500 | 5,000 | 333 | |
| C. albicans | 7 | >500 | 5,000 | 285 | |
| I5 (G) | C. albicans | 1 | 441 | 407 | 133 |
| C. albicans | 6 | 22 | 222 | 110 | |
| C. albicans | 10 | 38 | 336 | 300 | |
| I6 (G) | C. albicans | −5 | 108 | 403 | 70 |
| C. albicans | 0 | 150 | 283 | 85 | |
| C. albicans | 4 | 232 | 2,528 | 500 | |
| I7 (G) | C. albicans | 2 | >500 | 850 | 350 |
| C. albicans | 10 | >500 | 367 | 667 | |
| I8 (G) | C. albicans | 1 | 41 | 158 | 238 |
| C. albicans | 7 | 39 | 58 | 151 | |
| I9 (R) | C. albicans | 1 | 4 | >500 | 1,000 |
| I10 (R) | C. albicans | 2 | 0 | >500 | 385 |
| I11 (R) | C. albicans | 1 | 3 | >500 | 175 |
| C. albicans | 0 | 3 | >500 | 435 | |
| I12 (R) | C. albicans | 1 | >500 | >500 | 159 |
| I13 (R) | C. albicans | 1 | 0 | >500 | 122 |
| I14 (R) | C. glabrata | 0 | 64 | >500 | 78 |
| I15 (G) | C. tropicalis | 3 | >500 | 159 | 110 |
| C. tropicalis | 7 | 18 | 189 | 357 | |
| C. tropicalis | 14 | 31 | 42 | 345 | |
| I16 (R) | C. tropicalis | 3 | >500 | >500 | 714 |
| I17 (G) | C. parapsilosis | 2 | 5 | 61 | 53 |
| C. parapsilosis | 5 | 0 | 245 | 172 | |
| C. parapsilosis | 6 | 82 | 7 | 238 | |
| I18 (G) | C. parapsilosis | 1 | 16 | 125 | 122 |
| C. parapsilosis | 4 | 14 | 159 | 400 | |
| C. parapsilosis | 14 | 34 | 70 | 667 | |
| I19 (G) | C. parapsilosis | 0 | 21 | 26 | 159 |
| C. parapsilosis | 4 | 18 | 77 | 65 | |
| I20 (G) | C. parapsilosis | −1 | 110 | 39 | 833 |
| C. parapsilosis | 3 | 6 | 20 | 450 | |
| I21 (R) | C. parapsilosis | 1 | 2 | >500 | 1,000 |
| I22 (R) | C. parapsilosis | 1 | NA | >500 | 109 |
| C. parapsilosis | 1 | NA | >500 | 106 | |
| I23 (R) | C. parapsilosis | 7 | 256 | >500 | 333 |
| I24 (R) | C. parapsilosis | 0 | 0 | >500 | 96 |
| I25 (R) | C. orthopsilosis | 1 | >500 | >500 | 769 |
| C. orthopsilosis | 1 | >500 | >500 | 588 | |
| C. orthopsilosis | 1 | >500 | >500 | 1,000 | |
| C. orthopsilosis | 1 | >500 | >500 | 625 | |
| I26 (G) | C. krusei | 3 | 12 | 327 | 357 |
| C. krusei | 7 | 10 | 385 | 344 | |
| C. krusei | 10 | 8 | 191 | 400 | |
| I27 (G) | C. krusei | 2 | 12 | 7 | 300 |
| C. krusei | 4 | 16 | 14 | 167 |
a
BC, time of first positive blood culture; BDG, (1,3)-β-d-glucan; G, Genoa, Italy; Man, mannan; MS-DS, mass spectrometry method for detection of a serum disaccharide; NA, not available; R, Rome, Italy. Bold characters correspond to positive values.