TABLE 2.

Origin of the control sera used in the MS-DS test for invasive candidiasis^a

Patient no. (site)	Reason(s) for hospitalization	Risk factor(s) for fungal infection	Species isolated	Delay vs BC (days)	Man concn (pg/ml)	BDG concn (pg/ml)	MS-DS index
S1	Septic shock, infected kidney stone	Corticosteroids, panhypopituitarism (substitution)	Escherichia coli	−1	2	97	230
S2	Septic shock, urinary infection	MGUS, CRF, corticosteroids (unconfirmed Horton’s disease)	E. coli	0	3	83	286
S3	Cholangitis	Corticosteroids, polymyalgia rheumatica	E. coli	0	4	7	70
S4	Urosepsis	IDDM, PPI	E. coli	0	1	7	65
S5	Urosepsis	CRF, chronic ulcers, gout	E. coli	0	9	169	400
S6	Cholecystitis	PPI	E. coli	0	3	29	122
S7	Urosepsis	CRF, corticosteroids, polymyalgia rheumatica, PPI	E. coli	0	0	7	667
S8	Urosepsis	Indwelling urinary catheter	E. coli	0	0	122	43
S9	Skin infection	CRF	Streptococcus agalactiae	0	0	7	120
S10	Skin infection	None	Streptococcus dysgalactiae	0	2	7	154
S11	Skin infection	None	S. dysgalactiae	0	1	22	76
S12	Pneumococcal pneumonia	NIDDM	Streptococcus pneumoniae	0	3	7	55
S13	Pneumonia	None	Streptococcus pyogenes	0	4	7	500
S14	Plantar abscess	IDDM, metabolic syndrome	S. pyogenes	0	0	7	115
S15	Wound infection	IDDM, diffuse vascular disease, PPI	Staphylococcus aureus	0	4	280	238
S16	Endocarditis/spondylodiscitis	PPI	S. aureus	4	2	7	53
S17	Pyelonephritis	IDDM	Klebsiella pneumoniae	1	7	7	54
S18	Urosepsis	Indwelling urinary catheter	Proteus mirabilis	2	3	77	65
S19	Stroke, dental abscess	Diffuse cerebrovascular disease, PPI	Parvimonas micra	0	1	7	106
S20	Skin infection	IDDM, diffuse vascular disease	Corynebacterium spp.	0	4	7	104
S21	Cholangitis	None	Enterococcus faecalis, Enterobacter cloacae, Pseudomonas aeruginosa	0	2	7	115
L1	Pneumonia	Renal graft and leukemia	Nocardia nova	−2	0	35	72
L2	Skin infection and adenitis	Renal graft	N. nova	−5	0	2,336	131

^aBC, time of first positive blood culture; BDG, (1,3)-β-d-glucan; CRF, chronic renal failure; IDDM, insulin-dependent diabetes mellitus; L, Lille, France; Man, mannan; MGUS, monoclonal gammopathy of undetermined significance; MS-DS, mass spectrometry method for detection of a serum disaccharide; NNIDDM, non-insulin-dependent diabetes mellitus; PPI, proton pump inhibitor; S, Switzerland. Bold characters correspond to positive values.