TABLE 2.
Patient characteristics of PB-PC versus NB-PC
| Characteristics | PB-PC (n = 902) | NB-PC (n = 63) | P |
|---|---|---|---|
| Demographics | |||
| Age (mean ± SD), yr | 65 ± 22 | 64 ± 25 | 0.9936 |
| Pediatric (<18 yr) | 46 (5) | 4 (6) | 0.5612 |
| Neonate (<4 wk) | 14 (2) | 2 (3) | 0.2810 |
| Male, no. (%) | 488 (54) | 36 (55) | 0.6956 |
| BMI (mean ± SD), kg/m2 | 27.8 ± 0.7 | 25.4 ± 0.8 | 0.392 |
| Residence prior to admission, no. (%) | |||
| Home | 697 (77) | 48 (74) | 0.8766 |
| Skilled nursing or long-term care facility | 149 (17) | 14 (22) | 0.2280 |
| Outside hospital | 20 (2) | 0 (0) | 0.6353 |
| Homeless | 22 (2) | 0 (0) | 0.3913 |
| Past medical history, no. (%) | |||
| Prior hospitalization within 30 days | 70 (8) | 9 (14) | 0.0904 |
| Past bacteremiaa | 41 (5) | 0 (0) | 0.1040 |
| Comorbidity condition, no. (%) | |||
| ≥3 comorbidities | 551 (61) | 30 (47) | 0.0134 |
| Neurologic diseaseb | 171 (19) | 16 (25) | 0.2469 |
| Cardiovascular diseasec | 544 (60) | 35 (55) | 0.5065 |
| Pulmonary diseased | 153 (17) | 5 (8) | 0.0763 |
| Renal insufficiencye | 149 (17) | 8 (13) | 0.4855 |
| Liver disease | 68 (8) | 4 (6) | 1.0000 |
| Diabetes | 283 (31) | 12 (19) | 0.0469 |
| Ulcerative colitis/Crohn’s disease | 6 (0.7) | 2 (3) | 0.0910 |
| Malignancy | 176 (20) | 13 (20) | 0.8695 |
| Received chemotherapy within 90 days | 39 (4) | 2 (3) | 1.0000 |
| HIV/AIDS | 10 (1) | 1 (2) | 0.5261 |
| Admission characteristics | |||
| ICU at time of BioFire result, no. (%) | 151 (17) | 12 (19) | 0.6041 |
| Median SOFAf score (IQR) at time of blood culture collection, n | 9 (6–12), 175 | 7 (7–9.5), 7 | 0.8307 |
| Median qSOFAg score (IQR) at time of blood culture collection, n | 1 (1–2), 711 | 1 (1–2), 26 | 0.5312 |
| Diagnosis at time of blood culture collection | |||
| Sepsis | 271 (30) | 13 (21) | 0.1523 |
| UTI | 262 (29) | 16 (25) | 0.5689 |
| Pneumonia | 189 (21) | 11 (17) | 0.6305 |
| Acute bacterial skin and skin structure infections | 27 (3) | 8 (13) | 0.0773 |
| Systemic inflammatory response syndrome of unclear etiology | 99 (11) | 8 (13) | 0.6805 |
| Septic shock | 54 (6) | 3 (5) | 0.7917 |
| Intra-abdominal infection | 27 (3) | 3 (5) | 0.4133 |
The median (minimum, maximum) time period for past bacteremia for the PB-PC cohort was 172 days (24 days, 8.5 years).
Cerebral vascular accident, seizure disorder, encephalopathy, Parkinson’s disease, and Alzheimer’s disease.
Cardiac arrhythmia, hypertension, hyperlipidemia, dyslipidemia, hypercholesteremia, coronary artery disease, congestive heart failure, and prior myocardial infarction.
Chronic obstructive pulmonary disease, asthma, tracheostomy or vent dependent secondary to respiratory failure, and pulmonary circulation disorder.
End-stage renal disease or requiring hemodialysis.
Sepsis-related organ failure assessment score for those admitted to the ICU calculated within 24 h of positive blood culture collection time. IQR, interquartile range.
Quick sepsis-related organ failure assessment score for those not admitted to the ICU calculated within 24 h of positive blood culture collection time.