TABLE 3.
MFCs of isolates of the Southern Asian and South African clades, determined by endpoint plating of broth microdilution susceptibility tests
| Clade | Range (GM) MFC or MFC (mg/liter)a
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| AMB | FLC | ITC | VRC | PSC* | ISAV | AND | 5FC | NYT | TRB | |
| South African (n = 8) | 1 to 4 (1.68) | >64 (128) | 8 to >16 (22.6) | >16 (32) | 8 to >16 (22.6) | 16 to >16 (29.3) | 4 to >8 (11.3) | 1 to 32 (16) | 4 to 16 (6.6) | >16 (32) |
| Southern Asian (n = 17) | 1 to 16 (1.84) | >64 (128) | 8 to >16 (15.36) | >16 (32) | 2 to 4 (3.40) | 8 to >16 (15.36) | 2 to >8 (4.71) | 1 to >64 (3.40) | 4 to 32 (5.32) | >16 (32) |
| Japanese/Korean (n = 1) | 1 | >64 | 1 | 16 | 0.5 | 2 | 0.5 | 16 | 4 | >16 |
a
GM, geometric mean. *, P < 0.001 (2 sample t test) for GM of South African versus Southern Asian clade isolates. Antifungal drug abbreviations: AMB, amphotericin B; FLC, fluconazole; ITC, itraconazole; VRC, voriconazole; PSC, posaconazole; ISAV, isavuconazole; AND, anidulafungin; 5FC, flucytosine; NYT, nystatin; TRB, terbinafine.