TABLE 1.
Genes associated with astrocyte activation are upregulated in the brain following reovirus infection
| Function | Gene | Increase in expressiona
|
|
|---|---|---|---|
| Fold change | P | ||
| Astrocyte marker | GFAP | 5.44 | 9.93E–05 |
| Vim | 2.89 | 0.0003 | |
| Inflammation | TNFAIP9 | 22.4 | 0.005 |
| S1pr3 | 4.6 | 6.76E–05 | |
| Timp1 | 7.8 | 1.09E–05 | |
| Cxcl10 | 248.8 | 5.21E–07 | |
| Osmr | 4.9 | 0.0001 | |
| CCL5 | 195.9 | 0.0001 | |
| IL-6 | 31.4 | 0.0007 | |
| Innate immunity | Lcn2 | 386.2 | 7.61E–07 |
a
Increased expression of genes in reovirus-infected brains at 8 days p.i. compared to mock-infected controls was determined by microarray analysis (25).