FIG 6.

Neutralization characteristics of env recombinant. NL-VA40774 demonstrated sensitivity to bNAbs targeting the CD4bs, V3-glycans, and MPER, but interestingly was resistant to all V1/V2-glycan bNAbs. The concentrations of bNAb required for 50% neutralization of NL-VA40774 (IC₅₀) are shown in red, and IC₅₀ values of >50 µg/ml are shown in black. The V3-glycan antibody PGT128 was the most potent inhibitor of NL-VA40774, followed by CD4bs antibodies VRC07-523, 3BNC117, and VRC01. Continuing in order of decreasing potency, V3-glycan antibody 10-1074 is followed by MPER antibodies 2F5 and 4E10. The following antibodies did not neutralize NL-VA40774 (i.e., had IC₅₀s above 50 µg/ml): PG9, PG16, PGDM1400, CAP256-VRC26.25, PGT121, 8ANC195, 10E8, 17b, and 447-52D.