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. 2019 May 1;93(10):e00094-19. doi: 10.1128/JVI.00094-19

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Copyright © 2019 Silver et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 7 — Neutralization characteristics of NL-VA40774 and VA40774 plasma. (A) Serum from 10 HIV-infected individuals and plasma from 4 HIV elite controllers, including VA40774, were tested for their ability to neutralize NL-VA40774. VA40774 (blue) and two chronically infected individuals (red) were able to significantly neutralize NL-VA40774, while the remaining 12 patients were not able to neutralize NL-VA40774 (black). Titers that were >3-fold above the murine leukemia virus (MuLV) control levels were considered significant. (B) A single plasma sample from VA40774 was screened for its ability to neutralize two panels of HIV-1 Env pseudoviruses in TZM-bl neutralization assays. VA40774’s plasma exhibited markedly low neutralizing activity. Of the 25 viruses tested, VA40774’s plasma was capable of neutralizing only the tier 1A strain SF162.LS (red). The following viruses were not neutralized by VA40774’s plasma (black): BaL.26, 6535.3, QH0692.42, SC422661.8, AC10.0.29, RHPA4259.7, REJO4541.67, WITO4160.33, TRO.11, THRO4156.18, CAAN5342.A2, PVO.4, TRJO4551.58, 25710-2.43, 398-F1_F6_20, CNE55, Ce1176_A3, X1632_S2_B10, Ce703010217_B6, 246-F3_C10_2, CH119.10, X2278_C2_B6, CNE8, and BJOX002000.03.2.