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Proposed model of how the interaction between E1A and E4orf3 affects viral chromatin organization during infection. Brown discs represent histones, with the black line representing the viral DNA coiling around the core histones. mE1A, mutant E1A unable to bind to E4orf3; HDAC, histone deacetylase; HMT, histone methyl transferase; DNMT, DNA methyl transferase.
