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. 2019 Mar 13;6(9):1801361. doi: 10.1002/advs.201801361

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© 2019 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Single‐cell RNA Seq of U937‐derived macrophages during dynamic TLR4 immune activation. A,B) tSNE plots showing dynamic formation of two cellular substates in activated macrophages. Cluster 2 overlaps with resting macrophages while clusters 0 and 1 are distinct substates of activated macrophages. C) tSNE feature plots showing expression of marker genes of each cellular substate. D) Gene Ontology term enrichment analysis reveals differential expression of immune activation and ribosomal genes in two substates among activated human macrophages. E) Comparative analysis of single‐cell mRNA and protein secretion data.