Figure 7.

IR700‐YY146 PIT of small melanomas. A) ¹⁸F‐FDG PET imaging was performed 5 d after IR700‐YY146 PIT to compare glucose metabolism between the tumors in the control group and in the IR700‐YY146 PIT group. A representative tumor in the IR700‐YY146 PIT group did not show any ¹⁸F‐FDG uptake above background level (right panel). B) Quantitative analysis of tumor ¹⁸F‐FDG uptake in terms of SUVmax demonstrated statistical significance between the control group and the IR700‐YY146 PIT group. C) Tumor growth curves of A375 xenografts receiving different interventions. D) H&E and immunofluorescence staining of A375 tumors treated with saline. While H&E image showed high tumor cellularity, immunofluorescence images revealed substantial expression of CD146 in A375 cells. E) H&E and immunofluorescence staining of A375 tumors following IR700‐YY146 PIT. H&E image in this group otherwise showed extensive necrosis with scant cellularity, accompanied by reduced expression of CD146 in A375 cells revealed on immunofluorescent images. (**p < 0.01, ***p < 0.001, n = 4 for each group).