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. 2019 May 2;85(10):e02335-18. doi: 10.1128/AEM.02335-18

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Copyright © 2019 Alexander et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 1 — Assessment of potential biotherapeutic delivery vehicles. (a) Mutation rates of selected lactic acid bacteria determined by the FALCOR method (6). L. reuteri (Lre) exhibits a low mutation rate relative to other lactic acid bacteria, L. salivarius (Ls), L. gasseri (Lg), L. fermentum (Lf), L. jensenii (Lj), L. casei (Lc), L. rhamnosus (Lrh), L. acidophilus (La), L. plantarum (Lp), and L. lactis (Ll). *, P < 0.05; **, P < 0.01 (relative to L. reuteri). The results shown are averages from three independent experiments ± standard error. (b) LAB survival following GI transit in a mouse. L. reuteri [LR::rpoB(H488R)], L. rhamnosus, and L. plantarum survived GI transit at least 10-fold better than L. lactis (P < 0.001, Tukey’s HSD). Each dot represents a single mouse. Different letters indicate statistical differences between the respective treatment groups.