FIG 5.

In silico analyses of the fun and pks clusters. (A) Schematic representation of Lactobacillus and Streptococcus type II polyketide-like fatty acid BGCs. Genes are color-coded by predicted function. (B) Chemical structure of granadaene, produced by group B Streptococcus. The polyene chain is formed by 13 elongation rounds, conjugated to the nonproteinogenic amino acid ornithine, and terminally glycosylated with rhamnose. (C) Comparison of the proposed biosynthetic pathways and predicted compounds for fun and pks clusters.