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. 2019 Apr 26;10:394. doi: 10.3389/fgene.2019.00394

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Copyright © 2019 Nikoghosyan, Hakobyan, Hovhannisyan, Loeffler-Wirth, Binder and Arakelyan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characterization of the SNP landscape. (A) The spot summary map segments into 13 spots (see labels A–M) enriching minor-alleles in a population/geography specific way. (B) The positions of 17 SNPs referring to different genes selected from the top 40 genes having a high number of disease associations (Price et al., 2015) in the SOM are indicated by arrows. Accumulation of these genes in the spot areas is indicated by dashed circles. The profiles of selected SNPs reveal a population-specific enrichment of minor-allelic scores. (C) Mean allele profiles of the SNPs collected in each of the spots are shown as barplots. Each of the spots refers to a different profile. (D) Part of the spots can be assigned to one geographic region while ‘mixed’ spots show enrichment of minor alleles in populations from more than one region (see also the mean portraits in Figure 2A).