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. 2019 Apr 26;10:394. doi: 10.3389/fgene.2019.00394

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Copyright © 2019 Nikoghosyan, Hakobyan, Hovhannisyan, Loeffler-Wirth, Binder and Arakelyan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Associations of spots with diseases (A) and with geographic regions (B) are shown as heatmaps. Diseases represented with high numbers of SNPs in the background distribution accumulate in the lower part of the heatmap (A). More rarely-presented diseases frequently associate with one or two spots only (A) which, in turn, are assigned to specific regions according to the respective mean allele score (B). SNPs associated with mood disorders are enriched in spots having high MAF in Europeans and East Asians which corresponds to the enrichment of GO-terms related to neuronal functions in Figure 5.