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. 2019 Apr 26;10:939. doi: 10.3389/fimmu.2019.00939

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Copyright © 2019 Stronati, Palone, Negroni, Colantoni, Mancuso, Cucchiara, Cesi, Isoldi and Vitali.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DPG accelerates mucosal healing during recovery phase of DSS-induced acute colitis. C57BL/6 mice were treated with 3% DSS for 5 days and then were untreated or treated with DPG (8 mg/kg) for successive 9 days. Following parameters were analyzed: (A) weight loss; (B) colon length; (C) clinical score (stool consistency, presence of blood in stool and general appearance); (D) histological score; (E) morphology of the colon evaluated through histological analysis (40x magnification in the image). Five animals per experimental group were used. Statistical analysis: Kruskal-Wallis Test with Dunn's Multiple Comparisons post-Test. *p < 0.05, **p < 0.01. UN, untreated animals; DSS, dextran sulfate sodium; DPG, dipotassium glycyrrhizate.