Table 2.
List of the mucosal healing pathway genes analyzed.
| Gene | Fold regulation comparing DSS vs. UN | Fold regulation comparing DSS+DPG vs. DSS | |
|---|---|---|---|
| Cxcl3 | 1083.85 | −165.97 | |
| Il6 | 425.18 | −102.17 | |
| Csf3 | 335.14 | −55.9 | |
| Il1b | 204.88 | −37.48 | |
| Il10 | 60.91 | −9.35 | |
| Ifng | 49.13 | −2.87 | *Excluded DSS+DPG vs. DSS < 3.5 folds |
| Cxcl5 | 44.38 | −21.33 | |
| Cxcl1 | 28.68 | −37.57 | |
| Timp1 | 26.09 | −8.5 | |
| Ccl7 | 25.61 | −7.15 | |
| Tnf | 17.09 | −5.43 | |
| Plaur | 14.61 | −8.78 | |
| Ptgs2 | 13.04 | −30.87 | |
| Serpine1 | 10.55 | −9.77 | |
| Vtn | 8.43 | −40.55 | |
| Ccl12 | 7.88 | −10.94 | |
| Plat | 7.65 | −24.16 | |
| Mmp9 | 7.37 | −15.05 | |
| Hgf | 7.14 | −3.42 | * |
| Fgf2 | 5.32 | −27.25 | |
| Fgf7 | 5.02 | −28.67 | |
| Fga | 4.98 | −2.46 | * |
| Mmp7 | 4.87 | −1.11 | * |
| Col3a1 | 3.69 | −20.75 | |
| Tgfbr3 | 3.29 | −8.56 | From here excluded because DSS vs. UN < 3.5 folds |
| Cd40lg | 3.28 | 1.65 | |
| Mmp2 | 3.14 | −5.55 | |
| Tgfb1 | 3.12 | −2.9 | |
| Wisp1 | 3.1 | −7.63 | |
| Igf1 | 3.05 | −5.33 | |
| Il2 | 2.9 | −4.12 | |
| Col4a1 | 2.87 | −9.7 | |
| Fgf10 | 2.87 | −16.81 | |
| Cxcl11 | 2.84 | −13.16 | |
| Il4 | 2.77 | −7 | |
| F13a1 | 2.75 | −6.89 | |
| Itga4 | 2.55 | −4.43 | |
| Il6st | 2.44 | −4.13 | |
| Itgav | 2.43 | −5.09 | |
| Ctsk | 2.33 | −4.62 | |
| Ctsg | 2.21 | −1.09 | |
| Wnt5a | 2.2 | −6.11 | |
| Plau | 2.13 | −4.31 | |
| Angpt1 | 1.88 | −3.51 | |
| Col5a1 | 1.88 | −5.81 | |
| Plg | 1.87 | −1.14 | |
| Col1a1 | 1.86 | −2.32 | |
| Itgb6 | 1.81 | −3.41 | |
| Stat3 | 1.79 | −2.59 | |
| Egfr | 1.78 | −4.44 | |
| Itgb1 | 1.57 | −4.24 | |
| Col5a2 | 1.52 | −9.03 | |
| Itga5 | 1.52 | −4.78 | |
| Col1a2 | 1.44 | −6.2 | |
| Col5a3 | 1.39 | −6.06 | |
| Itga3 | 1.34 | −1.48 | |
| Itgb3 | 1.34 | −3.19 | |
| Itga2 | 1.17 | −1.89 | |
| Ctsl | 1.16 | −5.69 | |
| F3 | 1.13 | −3.34 | |
| Itgb5 | 1.13 | −2.25 | |
| Hbegf | 1.12 | −6.42 | |
| Mif | 1.07 | 1.42 | |
| Mmp1a | −1.01 | −3.83 | |
| Itga1 | −1.04 | −2.94 | |
| Vegfa | −1.14 | −1.39 | |
| Ctnnb1 | −1.22 | −1.76 | |
| Tagln | −1.23 | −3.85 | |
| Itga6 | −1.25 | −1.67 | |
| Ctgf | −1.28 | −11.17 | |
| Rhoa | −1.29 | −1.79 | |
| Pdgfa | −1.35 | −2.75 | |
| Col14a1 | −1.38 | −1.9 | |
| Pten | −1.4 | −3.28 | |
| Mapk3 | −1.44 | −1.06 | |
| Mapk1 | −1.44 | −1.51 | |
| Tgfa | −1.46 | −1.52 | |
| Cdh1 | −1.56 | −1.45 | |
| Rac1 | −1.66 | −3.12 | |
| Egf | −2.02 | −2.22 | |
| Csf2 | −2.03 | 1.57 | |
| Acta2 | −2.13 | −2.35 | |
| Col4a3 | −4.53 | −1.52 | |
| Actc1 | −6.72 | 1.21 |
Inclusion criteria for the genes were the following: fold-regulation comparing DSS vs. UN > 3.5 folds; furthermore for those included fold-regulation comparing DSS+DPG vs. DSS > 3.5.
The genes were shown in order of decreasing up-regulation comparing DSS vs. UN.
The genes positive for the inclusion criteria were highlighted in gray.
*
Genes excluded because DSS+DPG vs. DSS < 3.5 folds.