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. 2019 Apr 26;10:453. doi: 10.3389/fphar.2019.00453

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Copyright © 2019 Hu, Wang, Wang, Tai, Liu, Shao, Fang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The rat model of chronic post-ischemia pain (CPIP) showed persistent mechanical allodynia and thermal hyperalgesia. (A) Representative photographs of rat hind paw taken during CPIP model establishment and 10 min, 3 days, and 7 days after. The red arrow indicates the paw treated with the O ring. (B,C) Paw thickness evaluation of ipsilateral (B) and contralateral (C) paw of Sham and CPIP group rats. (D,E) 50% paw withdraw threshold (PWT, for measuring mechanical allodynia) of ipsilateral and contralateral paws of Sham and CPIP group rats. Panel (D) shows the PWT of ipsilateral hind paws and panel (E) shows the PWT of contralateral hind paws. (F,G) Paw withdraw latency (PWL, for measuring thermal hyperalgesia) of ipsilateral and contralateral paws of Sham and CPIP group rats. Panel (F) shows the PWL of ipsilateral hind paws and panel (G) shows the PWL of contralateral hind paws. n = 7 rats/group. ^∗p < 0.05, ^∗∗p < 0.01 vs. Sham group. Two-way ANOVA followed by Tukey’s post hoc test was used for statistical analysis.