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. 2019 Apr 26;10:453. doi: 10.3389/fphar.2019.00453

FIGURE 3.

FIGURE 3

Chronic post-ischemia pain (CPIP) enhanced TRPV1 channel currents in rat DRG neurons. (A) Representative current traces showing inward currents induced by TRPV1 agonist capsaicin (CAP, 100 nM) from DRG neurons of Sham and CPIP group, respectively. Current traces were obtained by continuous recording at a holding potential of –60 mV under whole cell voltage clamp. Dotted lines indicate zero current level. Timing of CAP application is indicated by black bars. (B) Summary of CAP (100 nM)-induced peak inward current density in DRG neurons from Sham and CPIP group rats. Current amplitude (pA) was normalized with corresponding cell capacitance (pF) to obtain current density (pA/pF). (C) Pie charts showing the percentage of CAP (100 nM)-responding neurons (red color) among all tested neurons. The number of neurons tested is as indicated. (D) Representative current traces showing inward currents induced by capsaicin (300 nM) from DRG neurons of Sham and CPIP group. (E) Summary for the CAP (300 nM)-induced peak inward current density in DRG neurons from Sham and CPIP group rats. (F) Pie charts showing the percentage of CAP (300 nM)-responding neurons (red color) among all tested neurons. The number of neurons tested is as indicated. ∗p < 0.05 vs. Sham group. Student’s t-test was used for statistical analysis.