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. 2019 Apr 26;10:453. doi: 10.3389/fphar.2019.00453

FIGURE 4.

FIGURE 4

TRPV1 specific antagonist AMG9810 attenuates thermal and mechanical hypersensitivity induced by CPIP model. (A) Time course effect of AMG9810 on paw withdraw latency (PWL) of ipsilateral paw of CPIP rats. AMG9810 (0.8 μg/paw, CPIP + AMG) or corresponding vehicle (0.1% DMSO in PBS, CPIP + Veh) was applied via intraplantar injection to ipsilateral hind paws of CPIP rats 40 min before measurement. AMG9810 or vehicle is applied daily after CPIP model establishment. (B) Summary of the normalized area under the curve (AUC) as in A. (C) Time course showing the effects of AMG9810 on paw withdraw latency (PWL) of contralateral paw of CPIP rats. (D) Summary of the normalized area under the curve (AUC) as in C. (E) Time course effect of AMG9810 on 50% paw withdraw threshold (PWT) of ipsilateral paw of CPIP rats. (F) Summary of the normalized AUC as in E. (G) Time course showing the effects of AMG 9810 on 50% PWT of contralateral paw of CPIP rats. (H) Summary of the normalized AUC as in G. ∗p < 0.05, ∗∗p < 0.01 vs. Sham group. #p < 0.05, ##p < 0.01 vs. CPIP + Veh group. n = 6 rats/group. Two-way ANOVA followed by Tukey’s post hoc test was used for statistical analysis.