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. 2019 Apr 26;10:453. doi: 10.3389/fphar.2019.00453

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Copyright © 2019 Hu, Wang, Wang, Tai, Liu, Shao, Fang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Locally applied low dosage of AMG9810 has no effect on locomotor activity or core body temperature. (A) Rat rotarod test to evaluate locomotor activity. AMG9810 was applied via intraplantar injection into the right hind paw (0.8 μg/paw in 25 μl volume) for a consecutive of 4 days from Day 1. Control group received vehicle (0.1% DMSO in PBS) treatment. 40 min after AMG9810 or vehicle treatment, rats were put on rotarod and tested. (B) Rectal temperature of rats measured by a digital thermometer. AMG9810 or vehicle was applied at dosages indicated above and applied at time points indicated by the black arrows. n = 6 rats/group. Two-way ANOVA followed by Tukey’s post hoc test was used for statistical analysis.