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. 2019 Apr 26;10:453. doi: 10.3389/fphar.2019.00453

FIGURE 7.

FIGURE 7

AMG9810 treatment attenuates bilateral astrocyte activation in spinal cord dorsal horn of CPIP rats. (A) Ipsilateral (upper panels) or contralateral (lower panels) SCDH stained with GFAP antibody showing astrocytes from Sham + Veh, CPIP + Veh, and CPIP + AMG group. Scale bar = 100 μm. (B,C) Summary of the normalized fluorescence intensity (%) of GFAP staining in ipsilateral (B) and contralateral (C) SCDH. (D,E) Summary of the number of astrocytes observed in ipsilateral (D) and contralateral (E) SCDH. n = 4 rats/group. p < 0.05 vs. Sham + Veh group. #p < 0.05 vs. CPIP + Veh group. One-way ANOVA followed by Tukey’s post hoc test was used for statistical analysis.