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. 2019 Apr 26;10:453. doi: 10.3389/fphar.2019.00453

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Copyright © 2019 Hu, Wang, Wang, Tai, Liu, Shao, Fang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AMG9810 treatment attenuates bilateral microglia activation in spinal cord dorsal horn of CPIP rats. (A) Ipsilateral (upper panels) or contralateral (lower panels) SCDH stained with OX42 antibody showing microglia from Sham + Veh, CPIP + Veh, and CPIP + AMG group. Scale bar = 100 μm. (B,C) Summary of the normalized fluorescence intensity (%) of OX42 staining in ipsilateral (B) and contralateral (C) SCDH. (D,E) Summary of the number of microglia observed in ipsilateral (D) and contralateral (E) SCDH. n = 4 rats/group. ^∗p < 0.05 vs. Sham + Veh group. ^#p < 0.05 vs. CPIP + Veh group. One-way ANOVA followed by Tukey’s post hoc test was used for statistical analysis.