Table 1.
Intrinsic electrogenic properties of small-sized DRG neurons of Sham + Veh, CPIP + Veh, and CPIP + AMG9810 groups of rats.
| Sham + Veh | CPIP + Veh | CPIP + AMG9810 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Mean | SEM | n | Mean | SEM | n | Mean | SEM | n | |
| Input resistance (MΩ) | 564.1 | 40.6 | 26 | 537.9 | 18.2 | 33 | 521.7 | 33.6 | 33 |
| Capacitance (pF) | 30.1 | 0.4 | 30 | 30.3 | 0.5 | 31 | 29.5 | 0.4 | 31 |
| RMP (mV) | -65.8 | 0.9 | 27 | -66.9 | 1.1 | 31 | -64.9 | 0.8 | 32 |
| AP amplitude (mV) | 118.5 | 1.8 | 32 | 119.0 | 2.7 | 30 | 120.7 | 2.2 | 30 |
| AHP amplitude (mV) | 25.1 | 1.2 | 32 | 25.5 | 0.5 | 26 | 24.2 | 0.9 | 31 |
| AP frequency (spikes/s, step protocol) | 0.9 | 0.1 | 30 | 2.4* | 0.4 | 30 | 1.3# | 0.2 | 30 |
| AP frequency (spikes/s, ramp protocol) | 2.1 | 0.2 | 31 | 5.1** | 0.4 | 30 | 2.7## | 0.3 | 30 |
| Threshold (pA, step protocol) | 439.5 | 21.6 | 37 | 249.0** | 8.1 | 32 | 352.9## | 20.8 | 32 |
| Threshold (pA, ramp protocol) | 726.6 | 20.5 | 30 | 424.4** | 23.3 | 31 | 529.5## | 33.9 | 30 |
AP, action potential; AHP, after hyperpolarization.
∗p < 0.05, ∗∗p < 0.01, compared with sham group; #p < 0.05, ##p < 0.01, compared with CPIP + Veh group.