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. 2019 Apr 30;11:3741–3751. doi: 10.2147/CMAR.S189558

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© 2019 Cheng et al. This work is published and licensed by Dove Medical Press Limited

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CLDN8 is overexpressed in CRC cell lines and clinical human CRC samples.

Notes: The results of qRT-PCR (A) and Western blotting analysis (B, C) showed that CLDN8 mRNA and protein levels were significantly higher in CRC cell lines (SW480, HT-29, Caco-2, HCT116, and SW620 cells) compared to normal colorectal epithelial cell line HCoEpiC. Western blotting and PCR analysis (D) and IHC staining (E, F) showed that CLDN8 protein and mRNA were overexpressed in CRC samples when compared with the corresponding adjacent normal tissues. *P<0.05 and **P<0.01 when compared with HCoEpiC or the normal tissue.

Abbreviations: CRC, colorectal cancer; IHC, immunohistochemistry; qRT-PCR, quantitative reverse transcription PCR.