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. 2019 May 3;18:77. doi: 10.1186/s12934-019-1127-8

Fig. 3.

Fig. 3

Engineering of the MVA module to enhance betulinic acid production. The genes ERG1, ERG9 and HMG1 in the MVA module were overexpressed individually or in combination. The light orange background represents strains generated from YLJCC5, and the reseda background represents strains generated from YLJCC6. Red and yellow blocks in the first column of the gene form represent the CYP/CPR and MVA modules, respectively. Asterisk represents the strains used in the final multimodular optimization