Table 4.

CSF marker stratified for extent of cSS.

	Disseminated cSS (n = 33)	Focal cSS (n = 29)	P-value	OR (95% CI)
Aß42 (pg/ml), median (IQR)	332 (269–421)	435 (367–679)	0.0006	0.02 [0.002–0.2]
Aß40 (pg/ml), median (IQR)	7,506 (6,784–8,901) (n = 23)	9,418 (7,986–14,621) (n = 21)	0.007	0.01 [0.0003–0.3]
T-tau (pg/ml), median (IQR)	322 (245–431)	309 (248–1214)	0.6	0.8 [0.3–2]
P-tau (pg/ml), median (IQR)	60 (51–67)	60 (51–90)	0.2	0.5 [0.1–1.6]
Aß42/40 ratio, median (IQR)	0.05 (0.04–0.06) (n = 23)	0.04 (0.04–0.08) (n = 21)	0.9	1.1 [0.2–4.9]

Logistic regression with adjustment for age, sex, number of cerebral microbleeds, MMSE, cholesterol, diabetes and hypertension. All CSF marker levels were log-transformed for regression analysis. Odds Ratios correspond to one unit increase in log-transformed levels. Where data were missing, the number of subjects for which data were available is indicated within parentheses. SD, standard deviation; t-tau, total tau; p-tau, phosphorylated tau; Aß42, ß-amyloid 1–42; Aß40, ß-amyloid 1–40; cSS, cortical superficial siderosis; CSF, Cerebrospinal fluid; MMSE, Mini Mental State Examination; OR, odds ratio; CI, confidence interval. Significant values are indicated in bold.